Amoxicillin 500mg

Description

Overview of Amoxicillin
Amoxicillin is a penicillin-class antibiotic used to treat infections which are caused by gram-positive and gram-negative aerobic bacteria.
Amoxicillin was initially approved by the United States in 1974. It is the best effective in the treatment of drug-resistant bacteria.
Amoxicillin is used to treat ear, skin, nose, throat, genito-urinary and lower respiratory tract infections.
Amoxicillin is available in various forms, such as capsules, tablets, chewable tablets, powder for oral suspension and paediatric drops for oral suspension. It is also available in injection forms with other combinational drugs, especially indicated to treat a few specific infections.
Amoxicillin uses
Amoxicillin and potassium clavulanate tablets uses are as follows:

Amoxicillin / Clavulanic acid is used for the treatment of susceptible bacterial infections of the skin, genitourinary tract, ear, nose, and throat.
Acute bacterial sinusitis, community-acquired pneumonia, lower respiratory tract infections, acute bacterial otitis media, skin infections, and urinary tract infections are treated with a combination of amoxicillin and clavulanate potassium.

Amoxicillin and potassium clavulanate tablets IP uses in combinational therapy are as follows:

Omeprazole and amoxicillin combination is used to treat Helicobacter pylori (H. Pylori) infection.
To treat H. pylori infection in adults, amoxicillin is used with vonoprazan and clarithromycin as co-packaged triple therapy or with vonoprazan as co-packaged dual therapy.
Amoxicillin uses | Amoxicillin tablet uses | Amoxicillin and potassium clavulanate tablets uses | Amoxicillin and potassium clavulanate uses
General considerations to follow while taking Amoxicillin
Amoxicillin clavulanate may be taken with or without food every 8 or 12 hours, depending on the type of condition and strength of the product, as prescribed by the physician.
Amoxicillin should be taken only for bacterial infections and not for viral infections (e.g., the common cold).
Using amoxicillin in the absence of a bacterial infection or as a prophylactic administration leads to the development of drug-resistant bacteria.
In the case of suspension, shake well before use so that the drug can be mixed with formula and water. To wet the powder, add about one-third of the required quantity of water (as per directions) for reconstitution and shake well. Add the remaining water and shake firmly one more time.
Avoid administering the drug if any hyper reaction is seen.
Take it at regular intervals daily to get a better result.
Do not take two doses at the same time, as it leads to adverse events.
In case of a missed dose (due to forgetfulness etc.), the next dose must be taken immediately as and when it is remembered.
In case of a missed dose (due to forgetfulness etc.), it is better to go for the next dose if there is less time gap between the previous and next schedule.
Follow the treatment chart as directed by the physician.
Amoxicillin mechanism of action
Amoxicillin shows a bactericidal (kills microorganisms) effect against susceptible organisms (bacteria that are unable to grow in the presence of the drug) during their stage of active multiplication. Amoxicillin mode of action is similar to ampicillin, and thus it works by preventing the synthesis of the mucopeptide (a protein responsible for the growth of bacteria) present in the cell wall, which in turn leads to the death of the bacteria.

Amoxicillin indications
Amoxicillin is indicated for:

Isolates of Streptococcus and Staphylococcus species that cause infections of the ear, nose, and throat.
Infections of the genitourinary tract due to isolates of Escherichia coli (E.coli), Proteus mirabilis, or Enterococcus faecalis.
Infections of the skin due to susceptible isolates of Streptococcus species, Staphylococcus species, or E. coli.
Infections of the lower respiratory tract (LRTI) due to susceptible isolates of Streptococcus species, S. pneumoniae, Staphylococcus species, or Haemophilus influenzae.
Helicobacter pylori infection and duodenal ulcer disease are treated in combination with clarithromycin and lansoprazole.
Amoxicillin dosage
Dosage forms & strengths of amoxicillin:

250 mg, 500 mg (Amoxicillin capsules)
500 mg, 875 mg (Amoxicillin tablet)
125 mg/5ml, 200 mg/5 ml, 250 mg/5ml, and 400 mg/5ml (oral solutions); each 5ml of reconstituted solution contains 125 mg, 200 mg, 250 mg, and 400 mg of the drug, respectively.
250 mg, 500 mg, 1g (injections).

Amoxicillin dosage for adults:

Ear/nose/throat/skin infection

Mild/moderate condition – 500 mg for every 12 hours or 250 mg for every 8 hours
Severe condition – 875 mg for every 12 hours or 500 mg for every 8 hours
Lower respiratory tract infection

Mild/ moderate condition – 875 mg for every 12 hours or 500 mg for every 8 hours
Severe condition – 875 mg every 12 hours or 500 mg every 8 hours
Helicobacter pylori (H. Pylori) infection

Moderate and severe condition – Triple therapy: 1g amoxicillin + 500 mg clarithromycin + 30 mg lansoprazole
H. Pylori infection and duodenal ulcer disease

Moderate and severe condition – Double therapy: 1g amoxicillin + 30 mg lansoprazole

Amoxicillin dose for paediatrics/children > 3 Months:

Ear/ nose /throat/skin infection

Mild/ moderate condition – 25 mg/kg/day in divided doses for every 12 hours or 20 mg/kg/day in divided doses for every 8 hours
Severe condition – 45 mg/kg/day in divided doses for every 12 hours or 40 mg/kg/day in divided doses for every 8 hours
Lower respiratory tract (LRT) infection

Mild/ moderate condition – 45 mg/kg/day in divided doses for every 12 hours or 40 mg/kg/day in divided doses
Severe condition – 45 mg/kg/day in divided doses for every 12 hours or 40 mg/kg/day in divided doses every 8 hours

Note: The above children dose is recommended for only the patients whose weight is less than 40kgs, but for the child patients with a weight more than 40kgs, the usual adult dose is recommended.

Amoxicillin dose in neonates and infants aged ≤ 12 weeks (≤ 3 months):

30 mg/kg/day orally every 12th hourly interval for 2 to 3 days.

Amoxicillin dose for renal impairment patients:

Renal impairment patients with glomerular filtration rate < 30 mL/min should not receive an 875 mg dose. Instead, they are administered with 500 mg or 250 mg every 12 hours based on the severity of the condition. Renal impairment patients with glomerular filtration rate <10 mL/min are administered with amoxicillin and potassium clavulanate tablets IP of 500 mg or 250 mg every 24 hours based on the severity of the condition. Haemodialysis patients are administered with amoxicillin 500 mg or amoxicillin 250 mg every 24 hours based on the severity of the condition. (Note: haemodialysis patients should receive an additional dose of amoxicillin during and after the completion of dialysis). There is currently no dosing schedule for renal impairment patients in children and paediatrics.